Depression can be a challenging journey, but new treatments offer hope. At Global Behavioral Healthcare, we’re excited to explore Spravato treatment for depression, a groundbreaking option for those who haven’t found relief with traditional antidepressants.
Spravato, also known as esketamine, works differently in the brain and has shown promising results for treatment-resistant depression. Let’s dive into what Spravato is, how it works, and what you can expect from this innovative therapy.
What is Spravato and How Does it Work?
A Revolutionary Approach to Depression Treatment
Spravato represents a breakthrough in depression treatment. This nasal spray medication offers hope for those who struggle with treatment-resistant depression. Unlike traditional antidepressants that often take weeks to show effects, Spravato can provide relief within hours or days.
At Global Behavioral Healthcare, we’ve witnessed the transformative power of Spravato for many patients who didn’t find success with other treatments. Spravato contains esketamine, a close relative of the anesthetic ketamine. While conventional antidepressants primarily target serotonin levels, Spravato takes a different approach by focusing on glutamate, a neurotransmitter linked to mood regulation and brain plasticity.
FDA Approval for Tough-to-Treat Depression
The FDA approved Spravato specifically for adults with treatment-resistant depression. This means it’s an option for individuals who have tried at least two other antidepressants without adequate improvement. Spravato isn’t a first-line treatment, but rather a powerful tool for those who have struggled to find relief through conventional methods.

The Science Behind Spravato’s Effectiveness
When a patient uses Spravato, it quickly increases glutamate activity in the brain. This boost in glutamate helps form new neural connections, potentially “rewiring” areas of the brain affected by depression. Research shows that this process can lead to significant improvements in mood and overall functioning.
Supervised Administration for Safety
It’s crucial to note that Spravato isn’t a take-home medication. Patients receive it under supervision at a certified healthcare facility (like our clinic at Global Behavioral Healthcare). This ensures patient safety and allows for monitoring of any side effects.
Personalized Treatment Approach
While Spravato offers hope for many, it’s not the right fit for everyone. At Global Behavioral Healthcare, we work closely with each patient to determine if Spravato® & Ketamine Therapy aligns with their unique situation. Our team guides patients through the entire treatment process, from initial evaluation to ongoing care.
As we move forward, let’s explore the specific steps involved in Spravato treatment and what patients can expect during their care journey.
How Does Spravato Treatment Work?
At Global Behavioral Healthcare, we’ve witnessed Spravato transform lives for those battling treatment-resistant depression. Let’s explore what you can expect from this innovative treatment.
Your Journey Starts with a Thorough Evaluation
Before you begin Spravato, you’ll meet with one of our experienced psychiatric providers for a comprehensive assessment. This isn’t a quick chat – we take time to understand your full mental health history, previous treatments, and current symptoms. We also review any medical conditions and medications to ensure Spravato is safe for you.
During this evaluation, we discuss your goals and address your concerns. It’s natural to have questions about a new treatment, and we provide clear, honest answers. If Spravato fits your needs, we create a personalized treatment plan tailored just for you.
The Spravato Administration Process
Spravato treatment happens in our clinic under close medical supervision. Here’s what a typical session looks like:
- You arrive at our comfortable, private treatment room.
- Our team checks your blood pressure and overall well-being.
- You self-administer the Spravato nasal spray with our guidance.
- You relax in our monitored recovery area for about two hours.
Most patients start with twice-weekly treatments for the first month, then transition to once-weekly or once every two weeks. Your exact schedule depends on how you respond to the medication.

Ongoing Monitoring and Support
Your safety and comfort are our top priorities. During each Spravato session, we closely monitor your vital signs and any side effects. The most common side effects include dizziness, nausea, and a temporary feeling of dissociation (these typically resolve within two hours).
Between treatments, we schedule regular check-ins to assess your progress. We use standardized depression scales to track improvements objectively. This allows us to fine-tune your treatment plan as needed.
Spravato as Part of a Comprehensive Approach
While Spravato can be powerful on its own, we often combine it with other evidence-based treatments for optimal results. This might include:
- Traditional antidepressants
- Individual or group therapy
- Lifestyle changes (sleep hygiene, exercise, nutrition)
- Stress reduction techniques
At Global Behavioral Healthcare, we believe in a holistic approach to mental health. Spravato nasal spray isn’t a magic bullet, but rather a tool that can jumpstart your recovery when combined with other supportive therapies.
The path to better mental health looks different for everyone. We’re here to guide you every step of the way, adjusting your treatment plan to help you achieve lasting wellness. As we move forward, let’s explore the potential benefits and side effects you should know about when considering Spravato treatment.
How Effective is Spravato for Depression?
Rapid Symptom Relief
Spravato stands out for its quick action against depression. Unlike traditional antidepressants that often require weeks to show effects, many patients report improvements within hours or days of their first Spravato treatment. A recent study assessed the efficacy and safety of esketamine monotherapy compared to placebo in reducing depressive symptoms.
This swift onset can transform lives, especially for those who have fought depression for years without adequate relief. However, individual responses vary, and some patients may need several treatments to experience full benefits.
Success Rates and Long-Term Effectiveness
Clinical trials show promising results for Spravato’s effectiveness in treating depression. FDA data indicates that about 70% of patients who received Spravato in combination with an oral antidepressant showed improvement in their depressive symptoms.
A long-term study suggests that some participants may be maintained with longer intervals between doses during long-term treatment. This indicates that Spravato may offer lasting benefits when used as part of a comprehensive treatment plan.

Managing Side Effects
Spravato, like all medications, can cause side effects. The most common include:
- Dizziness
- Nausea
- Dissociation (feeling disconnected from surroundings)
- Increased blood pressure
Healthcare providers take a proactive approach to manage these side effects. Patients receive close monitoring during and after each treatment session. Most side effects resolve within two hours of administration.
To minimize discomfort, patients should avoid eating for two hours before treatment and avoid drinking liquids for 30 minutes prior. A calm, comfortable environment for the post-treatment observation period also helps.
Safety Considerations for Long-Term Use
While Spravato has shown effectiveness, long-term safety data collection continues. The FDA requires ongoing monitoring through a Risk Evaluation and Mitigation Strategy (REMS) program. This ensures that Spravato’s benefits continue to outweigh potential risks.
Patients receiving Spravato treatment undergo regular health assessments (including blood pressure checks and evaluations for signs of substance abuse or worsening depression). Healthcare providers commit to staying up-to-date with the latest safety guidelines and research to provide the best possible care.
Spravato is not recommended for individuals with certain medical conditions, such as aneurysmal vascular disease or a history of intracerebral hemorrhage. A thorough medical evaluation is essential before starting treatment.
Final Thoughts
Spravato treatment for depression offers new hope for those who struggle with traditional methods. This innovative approach targets the brain differently, potentially providing rapid symptom improvement. At Global Behavioral Healthcare, we partner with our clients to create personalized treatment plans that address the whole person.
We encourage you to reach out if you want to explore whether Spravato aligns with your depression treatment goals. Our team offers comprehensive evaluations and answers your questions about this therapy option. Global Behavioral Healthcare stands ready to support you on your path to wellness.
Seeking help for depression shows strength. You don’t need to face this challenge alone. Our team commits to helping you find a way forward, whether through Spravato or another treatment that fits your needs better. Your mental health matters, and with the right support, brighter days lie ahead.





